DNA and Health Testing

BarMor's DNA tests all of our Male dogs and non-related females. In addition, they are checked by ophthalmologist and orthopedic vets yearly. We spare no expense in making sure our dogs are of the highest quality, to give you the best breeding possible, however we do not submit our results to Penn-Hip, OFA, or CERF per our veterinarians suggestion.

PRA-prcd disease information

 

Late form of Progressive Retinal Athrophy, called PRA-prcd (progressive rod-code degeneration), is just one of all retinal defects.

 

Rods degenerate at first. Affected dogs become night-blind. This is very often the first symptom that dog owners recognize. Dogs usually have poor sense of directions and they crash in things. Pupil is widely open even when direct ray of light hit the eye (dogs have shining eyes in pictures). Later, cones start degenerating. Final disease symptoms are cataracts and total blindness.

 

PRA-prcd defect arises after normal photoreceptors development. Degree of degeneration differs in parts of retina. Lower retina part is affected sooner and more than upper part (this is not obvious by ophthalmology examination). Disease recognition should be made during dog adolescence. Clinical diagnosis by electroretinogram (ERG) or opthalmoscopy of PRA-prcd can be difficult. ERG identifies affected animals sooner than opthalmoscopy.

 

PRA-prcd is a hereditary disease. Causal mutation G1298A in ninth canine chromosome (CFA9) PRA-prcd was recognized. This mutation is inherited as an autosomal recessive trait. That means the disease affects dogs with P/P genotype only. The dogs with P/N genotype are considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype distribution can be expected: 25 % N/N (healthy non-carriers), 25 % P/P (affected), and 50 % N/P (healthy carriers). Because of high risk of producing affected offspring, mating of two N/P animals (carriers) can not be recommended.

The disease cannot be cured, but it is possible to eliminate it through genetic testing of litters and proper choice of parents.

 

DNA testing is an advisable alternative to the clinical examination. The test can be performed only once in life of the animal, because the genotype does not change with age.

Breeding Strategies Fact Sheet
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